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Artif DNA PNA XNA. 2012 Apr-Jun;3(2):53-62. doi: 10.4161/adna.20158. Epub 2012 Apr 1.

PNA bearing 5-azidomethyluracil: a novel approach for solid and solution phase modification.

Author information

1
Dipartimento di Chimica Organica e Industriale, Università di Parma, Parma, Italy. alex.manicardi@unipr.it

Abstract

Fmoc- and Boc-protected modified monomers bearing 5-azidomethyluracil nucleobase were synthesized. Four different solid-phase synthetic strategies were tested in order to evaluate the application of this series of monomers for the solid-phase synthesis of modified PNA. The azide was used as masked amine for the introduction of amide-linked functional groups, allowing the production of a library of compounds starting from a single modified monomer. The azide function was also exploited as reactive group for the modification of PNA in solution via azide-alkyne click cycloaddition.

PMID:
22772040
PMCID:
PMC3429531
DOI:
10.4161/adna.20158
[Indexed for MEDLINE]
Free PMC Article
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