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Artif DNA PNA XNA. 2012 Apr-Jun;3(2):73-9. doi: 10.4161/adna.20727. Epub 2012 Apr 1.

Introduction of multiphosphonate ligand to peptide nucleic acid for metal ion conjugation.

Author information

1
Research Center for Advanced Science and Technology; The University of Tokyo, Tokyo, Japan.

Abstract

Peptide nucleic acid (PNA) is one of the most widely used synthetic DNA analogs. Conjugation of functional molecules to PNA is very effective to further widen its potential applications. For this purpose, here we report the synthesis of several ligand monomers and introduced them to PNA. These ligand-modified PNAs attract cerium ion and are useful for site-selective DNA hydrolysis. It should be noted that these ligands on PNA are also effective even under the conditions of invasion complex.

PMID:
22772037
PMCID:
PMC3429533
DOI:
10.4161/adna.20727
[Indexed for MEDLINE]
Free PMC Article

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