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Transcription. 2012 Sep-Oct;3(5):215-20. doi: 10.4161/trns.20914. Epub 2012 Sep 1.

Methylation muscles into transcription factor silencing.

Author information

1
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Abstract

The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.

KEYWORDS:

G9a; PRC2; chromatin modifiers; differentiation; methylation; skeletal muscle; transcription; transcription factors

PMID:
22771996
PMCID:
PMC3632615
DOI:
10.4161/trns.20914
[Indexed for MEDLINE]
Free PMC Article
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