Abstract
The active center of multi-subunit RNA polymerase consists of two modules, the Mg(2+) module, holding the catalytic Mg(2+) ion, and a module made of a flexible domain, the Trigger Loop. Uniquely, the TL module can be substituted by alternative modules, thus changing the catalytic properties of the active center.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalytic Domain
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Cations / metabolism
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DNA-Directed RNA Polymerases / genetics*
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DNA-Directed RNA Polymerases / metabolism*
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Escherichia coli / genetics
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Magnesium / metabolism
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Models, Molecular
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Protein Subunits / genetics*
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Protein Subunits / metabolism
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Thermus / genetics
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Transcription Factors
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Transcriptional Elongation Factors / genetics
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Transcriptional Elongation Factors / metabolism
Substances
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Cations
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Escherichia coli Proteins
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GreB protein, E coli
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Protein Subunits
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Transcription Factors
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Transcriptional Elongation Factors
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DNA-Directed RNA Polymerases
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Magnesium