Multiple active centers of multi-subunit RNA polymerases

Transcription. 2012 May-Jun;3(3):115-8. doi: 10.4161/trns.19887.

Abstract

The active center of multi-subunit RNA polymerase consists of two modules, the Mg(2+) module, holding the catalytic Mg(2+) ion, and a module made of a flexible domain, the Trigger Loop. Uniquely, the TL module can be substituted by alternative modules, thus changing the catalytic properties of the active center.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain
  • Cations / metabolism
  • DNA-Directed RNA Polymerases / genetics*
  • DNA-Directed RNA Polymerases / metabolism*
  • Escherichia coli / genetics
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Magnesium / metabolism
  • Models, Molecular
  • Protein Subunits / genetics*
  • Protein Subunits / metabolism
  • Thermus / genetics
  • Transcription Factors
  • Transcriptional Elongation Factors / genetics
  • Transcriptional Elongation Factors / metabolism

Substances

  • Cations
  • Escherichia coli Proteins
  • GreB protein, E coli
  • Protein Subunits
  • Transcription Factors
  • Transcriptional Elongation Factors
  • DNA-Directed RNA Polymerases
  • Magnesium