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Transcription. 2012 May-Jun;3(3):106-9. doi: 10.4161/trns.19816.

A conserved role for intragenic DNA methylation in alternative pre-mRNA splicing.

Author information

1
Mouse Cancer Genetics Program, NCI-Frederick, NIH, Frederick, MD USA. Shalini.oberdoerffer@nih.gov

Abstract

DNA methylome analysis in a variety of species has revealed elevated 5-methylcytosine at exons relative to introns. These associations raised the possibility that intragenic DNA methylation aids the spliceosome in the process of exon definition. Here, I highlight recent genome-wide associations and direct evidence linking DNA methylation to pre-mRNA splicing.

PMID:
22771943
PMCID:
PMC3616078
DOI:
10.4161/trns.19816
[Indexed for MEDLINE]
Free PMC Article

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