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Indian J Pathol Microbiol. 2012 Apr-Jun;55(2):215-7. doi: 10.4103/0377-4929.97876.

Viral markers in patients with hemophagocytosis: a prospective study in a tertiary care hospital.

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1
Department of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

Abstract

BACKGROUND:

Hemophagocytic syndrome (HPS) is a rare clinicopathological condition characterized by the activation of macrophages with prominent hemophagocytosis in bone marrow and other reticulo-endothelial systems. HPS can be familial or secondary to infections including viruses.

AIM:

To study the viral markers in patients with HPS.

MATERIALS AND METHODS:

Serum samples of patients with HPS and control group were screened for anti EBV VCA IgM, and IgG, anti-Parvo B19 IgM, and anti-CMV IgM antibodies using commercially available ELISA kits and CMV and ParvoB19 DNA by polymerase chain reaction (PCR).

RESULTS AND DISCUSSION:

The present prospective study reports the profile of viral markers in HPS cases from north India. Among the 14 HPS cases 43% (6/14) were positive for at least one viral marker tested, of which EBV was found to be the most prevalent (3/6: 50%) followed by parvovirus B19(2/6: 33%) and cytomegalovirus (1/6: 17%). Mortality was noted in 33% of virus associated HPS patients. Our study highlights the higher association of Epstein-Barr virus (EBV) with HPS as compared to other viruses along with higher rate of mortality in both parvovirus B 19 and EBV associated HPS.

PMID:
22771647
DOI:
10.4103/0377-4929.97876
[Indexed for MEDLINE]
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