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Allergol Immunopathol (Madr). 2013 Mar-Apr;41(2):73-85. doi: 10.1016/j.aller.2012.03.001. Epub 2012 Jul 6.

The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis.

Collaborators (276)

Aït-Khaled N, Anderson HR, Asher MI, Beasley R, Björkstén B, Brunekreef B, Crane J, Ellwood P, Flohr C, Foliaki S, Forastiere F, García-Marcos L, Keil U, Lai CK, Mallol J, Mitchell EA, Montefort S, Odhiambo J, Pearce N, Robertson CF, Stewart AW, Strachan D, von Mutius E, Weiland SK, Weinmayr G, Williams H, Wong G, Asher MI, Clayton TO, Ellwood P, Mitchell EA, Ellwood E, Stewart AW, Priftanji A, Benhabylès B, Baena-Cagnani CE, Crisci CD, Gómez M, Zabert GE, Robertson CF, Haidinger G, Howitt ME, Weyler J, Pinto-Vargas R, Bernhardt Cd, Borges WG, Camargos PA, Cardoso Md, d Cunha AJ, Fischer GB, Motta JM, Passos FJ, Pastorino AC, Porto Neto AC, Rosário N, Silva A, Solé D, Wandalsen N, de Britto M, de Freitas Souza L, Popov T, Kuaban C, Ferguson A, Rennie D, Goulding R, Standring P, Aguilar P, Amarales L, Benavides LA, Calvo MA, Contreras A, Chen YZ, Kunii O, Li Pan Q, Zhong NS, Aristizábal G, Cepeda AM, Ordoñez GA, M'Boussa J, Daniel R, Soto-Quirós ME, Koffi BN, Lah Tomulic K, Varona Peréz P, Barba S, Bustos C, Naguib ML, Figueroa Colorado M, Riikjärv MA, Melaku K, Sa'aga-Banuve R, Pekkanen J, Vlaski E, Hypolite IE, Gotua M, Keil U, Tsanakas J, Bueso-Engelhardt A, Lau YL, Wong G, Novák Z, Zsigmond G, Awasthi S, Bhave S, Chhatwal J, Hanumante NM, Jain KC, Joshi MK, Khatav VA, Kumar L, Mantri SN, Pherwani AV, Rego S, Sabir M, Salvi S, Setty G, Sharma SK, Singh V, Sukumaran TU, Suresh Babu PS, Kartasasmita CB, Konthen P, Suprihati W, Masjedi MR, Steriu A, Armenio L, Bisanti L, Bonci E, Chellini E, Ciccone G, Dell'Orco V, Forastiere F, Galassi C, Giannella G, La Grutta S, Petronio MG, Piffer S, Sestini P, Odajima H, Sohei M, Abu-Ekteish F, Esamai FO, Ng'ang'a L, Foliaki S, al-Momen JA, Imanalieva C, Sulaimanov S, Svabe V, Bojarskas J, Kudzyte J, Quah BS, Teh KH, de Bruyne J, Montefort S, Baeza-Bacab M, Barragán-Meijueiro M, Del-Río-Navarro BE, García-Almaráz R, González-Díaz SN, Linares-Zapién FJ, Merida-Palacio JV, Ramírez-Chanona N, Romero-Tapia S, Romieu I, Bouayad Z, Engels R, Asher MI, MacKay R, Moyes C, Pattemore P, Pearce N, Sánchez JF, Onadeko BO, Magatogia M, Annesi-Maesano I, Mahmood N, Yusuf MO, El Sharif N, Mortaja S, Cukier G, Guggiari-Chase JA, Chiarella P, Cua-Lim F, Brêborowicz A, Lis G, Annesi-Maesano I, Chiera ML, Câmara R, Lopes dos Santos JM, Nunes C, Rosado Pinto J, Clancy L, Kayembe JM, Annesi-Maesano I, Deleanu D, Kondiourina EG, Sow OY, Fuimaono V Pisi P, Adzovic O, Hadnadjev M, Panic E, Zivanovic S, Zivkovic Z, Goh DY, Voyi K, Zar HJ, Lee HB, Arnedo-Pena A, Batlles-Garrido J, Blanco-Quirós A, Busquets RM, Carvajal-Urueña I, García-Hernández G, García-Marcos L, González Díaz C, Guillén-Grima F, López-Silvarrey Varela A, Morales Suárez-Varela MM, Pérez-Yarza EG, Gunasekera KD, Musa OA, Al-Rawas O, Vogt H, Mohammad S, Mohammad Y, Tabbah K, Huang JL, Kao CC, Kongpanichkul A, Nettagul R, Prasarnphanich T, Teeratakulpisarn J, Trakultivakorn M, Vichyanond P, Tidjani O, Iosefa T, Monteil MA, Jerray M, Khaldi F, Redding GJ, Windom HH, Yeatts K, Ognev V, Anderson HR, Austin JB, Burr M, Shamssain MH, Strachan D, Holgado D, Lapides MC, Aldrey O, Vaên Cam B, Sears MR, Anderson HR, Aguirre V, Mallol J, Ahel V, Waqatakirewa L, Gratziou C, Lai CK, Anderson HR, Shah J, Baratawidjaja K, Nishima S, Fakakovi T, Otten R, Barny S, Chansin R, Manning P, Okiata JP, Catteau C, Khaitov RM, Tuuau-Potai N, Lee B, El Sony A, Nilsson L.

Author information

1
Department of Paediatric Respiratory Medicine, Hospital CRS El Pino, University of Santiago de Chile, Chile. jmallol@vtr.net

Abstract

This ISAAC Phase Three synthesis provides summarised information on the main findings of the study, regional tables and figures related to the prevalence and severity of current symptoms of asthma, rhinoconjunctivitis and eczema in the main regions of the world. The large number of surveyed children (≈1,200,000), the large number of centres (233) and countries (98) that participated in ISAAC Phase Three makes this study the most comprehensive survey of these diseases ever undertaken. Globally, the prevalence for current asthma, rhinoconjunctivitis and eczema in the 13-14-year age group was 14.1%, 14.6% and 7.3%, respectively. In the 6-7-year age group the prevalence for current asthma, rhinoconjunctivitis and eczema was 11.7%, 8.5% and 7.9%, respectively. The study shows a wide variability in the prevalence and severity of asthma, rhinoconjunctivitis and eczema which occurs not just between regions and countries but between centres in the same country and centres in the same city. This study definitively establishes that the prevalence of those diseases can be very high in non-affluent centres with low socioeconomic conditions. The large variability also suggests a crucial role of local environment characteristics to determine the differences in prevalence between one place and another. Thus, ISAAC Phase Three has provided a large body of epidemiological information on asthma, rhinoconjunctivitis and eczema in childhood from contrasting environments which is expected to yield new clues about the aetiology of those conditions and reasons for their marked global variability.

PMID:
22771150
DOI:
10.1016/j.aller.2012.03.001
[Indexed for MEDLINE]
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