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Eur J Med Chem. 2012 Aug;54:931-5. doi: 10.1016/j.ejmech.2012.06.025. Epub 2012 Jun 23.

Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues.

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Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rock lands, Ooty 643 001, Tamilnadu, India.


Stearic acid, a saturated fatty acid was isolated from the microalga Spirulina platensis. Some novel stearic acid analogues having 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole are synthesized and characterized by IR, NMR and mass spectral analysis. All the synthesized compounds were screened for antimicrobial activity by using cup plate method. The synthesized compounds have been further screened for their antidepressant activity in swiss albino mice by forced swim test (FST), midbrain dopamine has been estimated and quantified. All the compounds showed good antimicrobial activity and compound 6 showed significant antidepressant activity.

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