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Cell Stem Cell. 2012 Jul 6;11(1):9-15. doi: 10.1016/j.stem.2012.06.012.

Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.

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  • 1Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.


Human somatic cells can be reprogrammed into induced pluripotent stem cells (hiPSCs) with wide lineage differentiation potential in culture. However, reprogramming and long-term culture can also induce abnormalities in these pluripotent cells. This minireview discusses recent studies that have identified changes in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how understanding the sources and consequences of epigenetic variability in hiPSCs will impact disease modeling and clinical application in the future.

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