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Cell Stem Cell. 2012 Jul 6;11(1):7-8. doi: 10.1016/j.stem.2012.06.013.

Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21.

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1
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1202, USA.

Abstract

Despite having well-characterized disease-associated mutations, the mechanisms underlying the progressive bone marrow failure and cancer susceptibility of Fanconi anemia have been unclear. In this issue of Cell Stem Cell, Ceccaldi et al. identify an overactive p53/p21 stress response and cell cycle arrest as an underlying cause that starts during fetal development.

PMID:
22770237
PMCID:
PMC3402214
DOI:
10.1016/j.stem.2012.06.013
[Indexed for MEDLINE]
Free PMC Article
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