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J Diabetes Sci Technol. 2012 May 1;6(3):712-5.

The challenges of measuring glycemic variability.

Author information

1
Biomedical Informatics Consultants LLC, Potomac, Maryland 20854-4721, USA. drodbard@comcast.net

Abstract

This commentary reviews several of the challenges encountered when attempting to quantify glycemic variability and correlate it with risk of diabetes complications. These challenges include (1) immaturity of the field, including problems of data accuracy, precision, reliability, cost, and availability; (2) larger relative error in the estimates of glycemic variability than in the estimates of the mean glucose; (3) high correlation between glycemic variability and mean glucose level; (4) multiplicity of measures; (5) correlation of the multiple measures; (6) duplication or reinvention of methods; (7) confusion of measures of glycemic variability with measures of quality of glycemic control; (8) the problem of multiple comparisons when assessing relationships among multiple measures of variability and multiple clinical end points; and (9) differing needs for routine clinical practice and clinical research applications.

PMID:
22768904
PMCID:
PMC3440043
DOI:
10.1177/193229681200600328
[Indexed for MEDLINE]
Free PMC Article

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