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Cell Mol Life Sci. 2013 Jan;70(2):239-55. doi: 10.1007/s00018-012-1042-1. Epub 2012 Jul 6.

Prevention or acceleration of type 1 diabetes by viruses.

Author information

1
Université Paris Descartes, [corrected] Hôpital Saint Vincent de Paul/Cochin, Bâtiment [corrected] Petit, 82 Avenue Denfert-Rochereau 75014, Paris, France. liana.ghazarian@inserm.fr

Erratum in

  • Cell Mol Life Sci. 2013 Jan;70(2):257.

Abstract

Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Even though extensive scientific research has yielded important insights into the immune mechanisms involved in pancreatic β-cell destruction, little is known about the events that trigger the autoimmune process. Recent epidemiological and experimental data suggest that environmental factors are involved in this process. In this review, we discuss the role of viruses as an environmental factor on the development of type 1 diabetes, and the immune mechanisms by which they can trigger or protect against this pathology.

PMID:
22766971
DOI:
10.1007/s00018-012-1042-1
[Indexed for MEDLINE]

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