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Chem Commun (Camb). 2012 Aug 28;48(67):8320-2. doi: 10.1039/c2cc34181f. Epub 2012 Jul 6.

Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.

Author information

1
Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.

Abstract

Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.

PMID:
22766607
DOI:
10.1039/c2cc34181f
[Indexed for MEDLINE]

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