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FEMS Microbiol Lett. 2012 Oct;335(1):11-8. doi: 10.1111/j.1574-6968.2012.02632.x. Epub 2012 Aug 2.

Diversity of 5S rRNA genes within individual prokaryotic genomes.

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1
New York University College of Arts and Science, New York, NY, USA.

Abstract

We examined intragenomic variation of paralogous 5S rRNA genes to evaluate the concept of ribosomal constraints. In a dataset containing 1161 genomes from 779 unique species, 96 species exhibited > 3% diversity. Twenty-seven species with > 10% diversity contained a total of 421 mismatches between all pairs of the most dissimilar copies of 5S rRNA genes. The large majority (401 of 421) of the diversified positions were conserved at the secondary structure level. The high diversity was associated with partial rRNA operon, split operon, or spacer length-related divergence. In total, these findings indicated that there are tight ribosomal constraints on paralogous 5S rRNA genes in a genome despite of the high degree of diversity at the primary structure level.

PMID:
22765222
PMCID:
PMC3439594
DOI:
10.1111/j.1574-6968.2012.02632.x
[Indexed for MEDLINE]
Free PMC Article
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