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Case Rep Med. 2012;2012:375730. doi: 10.1155/2012/375730. Epub 2012 Jun 12.

Chest pain and costochondritis associated with vitamin d deficiency: a report of two cases.

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  • 1Department of Family Medicine, Tripler Army Medical Center, Honolulu, HI 96859, USA.


Vitamin D is integral for bone health, and severe deficiency can cause rickets in children and osteomalacia in adults. Although osteomalacia can cause severe generalized bone pain, there are only a few case reports of chest pain associated with vitamin D deficiency. We describe 2 patients with chest pain that were initially worked up for cardiac etiologies but were eventually diagnosed with costochondritis and vitamin D deficiency. Vitamin D deficiency is known to cause hypertrophic costochondral junctions in children ("rachitic rosaries") and sternal pain with adults diagnosed with osteomalacia. We propose that vitamin D deficiency may be related to the chest pain associated with costochondritis. In patients diagnosed with costochondritis, physicians should consider testing and treating for vitamin D deficiency.

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