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Front Oral Biol. 2012;16:60-70. doi: 10.1159/000337617. Epub 2012 Jun 25.

Roles of BMP signaling pathway in lip and palate development.

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1
Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA.

Abstract

Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are severe disruptions affecting orofacial structures. Patients with orofacial clefts require complex interdisciplinary care, which includes nursing, plastic surgery, maxillofacial surgery, otolaryngology, speech therapy, audiology, psychological and genetic counseling, orthodontics and dental treatment, among others. Overall, treatment of clefts of the lip and palate entails a significant economic burden for families and society. Therefore, prevention is the ultimate objective and this will be facilitated by a complete understanding of the etiology of this condition. Here we review the current concepts regarding the genetic and environmental factors contributing to orofacial clefts and emphasize on the roles of BMP signaling pathway components in the normal and aberrant development of the lip and palate.

PMID:
22759670
PMCID:
PMC3661199
DOI:
10.1159/000337617
[Indexed for MEDLINE]
Free PMC Article
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