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Hepatology. 2012 Dec;56(6):2404-11. doi: 10.1002/hep.25929.

Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver.

Author information

1
Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro (CH), Italy.

Abstract

Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver.

PMID:
22753116
DOI:
10.1002/hep.25929
[Indexed for MEDLINE]

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