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Mol Imaging Biol. 2013 Feb;15(1):12-8. doi: 10.1007/s11307-012-0574-y.

Automated radiosynthesis of [(18)F]ML-10, a PET radiotracer dedicated to apoptosis imaging, on a TRACERLab FX-FN module.

Author information

1
CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, 14074 Caen, France. sobrio@cyceron.fr

Abstract

PURPOSE:

[(18)F]ML-10 is the most advanced radiopharmaceutical for the clinical imaging of the apoptosis phenomenon by PET. The preparation of this radiopharmaceutical on a commercial radiosynthesis module and the requested quality controls for its release are presented herein.

PROCEDURES:

ML-10 as reference and its mesyloxy derivative as precursor for labelling with fluorine-18 were prepared. [(18)F]ML-10 was synthesized via a [(18)F]fluorine-de-mesyloxy aliphatic nucleophilic substitution via a GE TRACERLab® FX-FN module. Quality controls were performed.

RESULTS:

The labelling precursor was obtained in a four step synthesis in 28 % overall yield affording ML-10 in two steps (88 % yield). Pure [(18)F]ML-10 was obtained with a decay corrected yield of 39.8 % ± 8.4 % (n = 7) in 70 min and a specific activity of 235 ± 85 GBq/μmol at the end of synthesis.

CONCLUSIONS:

[(18)F]ML-10 was prepared on a widely available automated module and passed the quality control. A LC/MS method was developed to measure specific radioactivity.

PMID:
22752653
DOI:
10.1007/s11307-012-0574-y
[Indexed for MEDLINE]
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