Abstract
Two marketed antimicrobial-coated Foley catheters were compared for in vitro diffusible and contact-dependent inhibition of 11 urinary tract infection-associated microorganisms in an adherence-biofilm assay. Nitrofurazone-coated catheters significantly outperformed silver alloy-coated catheters for inhibitory activity, according to both inoculum broth and catheter sonicate counts, whether compared directly or against the corresponding control catheters. Although inhibition waned with catheter preincubation in saline, some organisms were inhibited even after a 48-h catheter preincubation, especially by the nitrofurazone-coated catheter.
MeSH terms
-
Alloys / chemistry
-
Anti-Infective Agents / pharmacology*
-
Bacterial Adhesion / drug effects
-
Biofilms / drug effects
-
Biofilms / growth & development
-
Candida albicans / drug effects
-
Candida albicans / growth & development
-
Catheters, Indwelling / microbiology*
-
Coated Materials, Biocompatible / pharmacology*
-
Gram-Negative Bacteria / drug effects
-
Gram-Negative Bacteria / growth & development
-
Gram-Positive Bacteria / drug effects
-
Gram-Positive Bacteria / growth & development
-
Humans
-
Microbial Sensitivity Tests
-
Nitrofurazone / pharmacology*
-
Silver / chemistry
-
Urinary Catheterization*
-
Urinary Tract Infections / drug therapy
-
Urinary Tract Infections / microbiology
-
Urinary Tract Infections / prevention & control*
Substances
-
Alloys
-
Anti-Infective Agents
-
Coated Materials, Biocompatible
-
Silver
-
Nitrofurazone