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Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a012245. doi: 10.1101/cshperspect.a012245.

From cis-regulatory elements to complex RNPs and back.

Author information

1
Gene Regulation Programme, Centre for Genomic Regulation (CRG) and UPF, 08003-Barcelona, Spain. fatima.gebauer@crg.eu

Abstract

Messenger RNAs (mRNAs), the templates for translation, have evolved to harbor abundant cis-acting sequences that affect their posttranscriptional fates. These elements are frequently located in the untranslated regions and serve as binding sites for trans-acting factors, RNA-binding proteins, and/or small non-coding RNAs. This article provides a systematic synopsis of cis-acting elements, trans-acting factors, and the mechanisms by which they affect translation. It also highlights recent technical advances that have ushered in the era of transcriptome-wide studies of the ribonucleoprotein complexes formed by mRNAs and their trans-acting factors.

PMID:
22751153
PMCID:
PMC3385959
DOI:
10.1101/cshperspect.a012245
[Indexed for MEDLINE]
Free PMC Article

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