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Nat Neurosci. 2012 Jul 1;15(8):1117-9. doi: 10.1038/nn.3153.

Corticostriatal functional connectivity predicts transition to chronic back pain.

Author information

1
Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

Abstract

The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

PMID:
22751038
PMCID:
PMC3411898
DOI:
10.1038/nn.3153
[Indexed for MEDLINE]
Free PMC Article

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