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Nat Neurosci. 2012 Jul 1;15(8):1111-3. doi: 10.1038/nn.3151.

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities.

Author information

1
Department of Neurobiology, Interdisciplinary Centre for Neurosciences, University of Heidelberg, Heidelberg, Germany.

Abstract

Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.

PMID:
22751036
DOI:
10.1038/nn.3151
[Indexed for MEDLINE]
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