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J Infect. 2012 Nov;65(5):400-5. doi: 10.1016/j.jinf.2012.06.010. Epub 2012 Jun 28.

Identical MALDI TOF MS-derived peak profiles in a pair of isogenic SCCmec-harboring and SCCmec-lacking strains of Staphylococcus aureus.

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Institute for Hygiene and Microbiology, Dept. of Medical Microbiology, Ruhr-University Bochum, Universitätsstraße 150, 44802 Bochum, Germany.


MALDI-TOF MS-based peak differences in oxacillin-resistant Staphylococcus aureus and oxacillin-susceptible S. aureus isolates have been described previously. Unfortunately, these isolates were not isogenic with respect to their mecA gene. Ours is the first to use a SCCmec-harboring parent and a SCCmec-lacking daughter strain, with the same genetic background, to unequivocally rule out strain-specific protein peaks. We could not show differences in the peak profiles within the preset Biotyper settings used for MALDI-TOF-based identification in this pair of SCCmec-harboring parent and SCCmec-lacking daughter strains.

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