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Neurochem Int. 2012 Oct;61(5):731-8. doi: 10.1016/j.neuint.2012.06.014. Epub 2012 Jun 27.

Scaffold protein Homer 1: implications for neurological diseases.

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Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.


Homer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction. Both an immediate-early gene encoding a Homer 1 variant and a constitutively expressed Homer 1 variant regulate receptor clustering and trafficking, intracellular calcium homeostasis, and intracellular molecule complex formation. Substantial preclinical investigations have implicated that each of these Homer 1 variants are associated with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, drug-induced addiction, and traumatic brain injury.

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