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Joint Bone Spine. 2013 Jan;80(1):44-7. doi: 10.1016/j.jbspin.2012.04.001. Epub 2012 Jun 29.

Kimura's disease and Behcet's syndrome in the same family--are they associated?

Author information

1
Department of Medicine, Rheumatology Unit, Hadassah-Hebrew University Medical Center Head, POB 12000, Jerusalem, Israel. eldad@hadassah.org.il

Abstract

BACKGROUND:

Behcet's disease (BD) and Kimura's disease (KD) are two inflammatory diseases commonly found in Japan. In Israel, both diseases are quite rare. Recently, we encountered a family whose three siblings suffer from BD and an additional brother suffers from KD. This observation raised the question as to whether both diseases have a common underlying genetic basis.

AIM OF THE STUDY:

To describe this unique family and to search for possible common alleles in the IL10 gene between BD and KD, as several SNPs in this gene are known to be associated with BD.

METHODS:

Three BD siblings and their brother with KD were interviewed and examined. Genomic DNA was prepared from blood samples taken from all nine members of the family. The DNA was genotyped for sequence variations of six SNPs on the IL10 gene.

RESULTS:

The IL10 SNPs did not segregate with BD and KD suggesting that there was no association between the IL10 gene and these diseases in this family.

CONCLUSIONS:

SNPs in the IL10 gene shown to be susceptibility factors in adult BD were not associated with BD in this family. The question regarding a possible common genetic basis for KD and BD requires further investigation.

PMID:
22749664
DOI:
10.1016/j.jbspin.2012.04.001
[Indexed for MEDLINE]

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