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Mol Cell. 2012 Jun 29;46(6):717-9. doi: 10.1016/j.molcel.2012.06.001.

Translational homeostasis via eIF4E and 4E-BP1.

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1
Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. ahinnebusch@nih.gov

Abstract

In this issue of Molecular Cell, Yanagiya et al. (2012) describe a regulatory mechanism that couples the abundance of the translational repressor 4E-BP1 with its target eIF4E via proteasomal degradation of 4E-BP1, thus maintaining translation in cells depleted of eIF4E.

PMID:
22749396
DOI:
10.1016/j.molcel.2012.06.001
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