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Fertil Steril. 2012 Oct;98(4):858-62. doi: 10.1016/j.fertnstert.2012.05.046. Epub 2012 Jun 29.

Early progesterone cessation after in vitro fertilization/intracytoplasmic sperm injection: a randomized, controlled trial.

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1
IVI Madrid, Madrid, Spain.

Abstract

OBJECTIVE:

To investigate the effect of stopping progesterone (P) support at week 5 versus week 8 on ongoing pregnancy rate after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

DESIGN:

Prospective, randomized, controlled trial.

SETTING:

University-affiliated infertility center.

PATIENT(S):

A total of 220 patients with intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI.

INTERVENTION(S):

Luteal phase support with micronized vaginal P was suspended at week 5 or at week 8.

MAIN OUTCOME MEASURE(S):

Ongoing pregnancy rate, miscarriage rate, and number of bleeding episodes.

RESULT(S):

Progesterone levels were similar on the day of the first pregnancy ultrasound exam (149 ± 108 vs. 167 ± 115 ng/mL). Significantly more bleeding episodes were observed in the first trimester in the group with early cessation of P supplementation (18.0 ± 2.6 vs. 7.2 ± 1.3 episodes). Miscarriage rates among singleton pregnancies were similar in the two groups (5/80 vs. 6/79).

CONCLUSION(S):

Vaginal P supplementation after IVF/ICSI can be safely withdrawn at 5 weeks' gestation, because cycle outcome was similar to conventional luteal phase support up to 8 weeks of pregnancy.

CLINICAL TRIAL REGISTRATION NUMBER:

NCT01177904.

[Indexed for MEDLINE]
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