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Fertil Steril. 2012 Sep;98(3):632-7. doi: 10.1016/j.fertnstert.2012.05.043. Epub 2012 Jun 29.

Comparison of two ready-to-use systems designed for sperm-hyaluronic acid binding selection before intracytoplasmic sperm injection: PICSI vs. Sperm Slow: a prospective, randomized trial.

Author information

1
Reproductive Medicine Unit, GynePro Medical Centers, Bologna, Italy. l.parmegiani@gynepro.it

Abstract

OBJECTIVE:

To compare, in a strict, randomized way, the efficiency of two ready-to-use systems for hyaluronic acid (HA)-intracytoplasmic sperm injection (ICSI): an HA culture dish (PICSI Sperm Selection Device) and a viscous medium containing HA (Sperm Slow).

DESIGN:

Prospective, randomized study.

SETTING:

Medical center.

PATIENT(S):

Fifty subjects per treatment group (100 total).

INTERVENTION(S):

One hundred ICSI treatments were randomly carried out with PICSI or with Sperm Slow for sperm selection. Randomization was conducted with sealed envelopes. Intracytoplasmic sperm injection was performed by a single embryologist with 5 years' experience in HA-ICSI.

MAIN OUTCOME MEASURE(S):

PRIMARY OUTCOME MEASURE:

good-quality embryo rate.

SECONDARY OUTCOME MEASURES:

oocyte fertilization, pregnancy and implantation rate, and the duration of the ICSI procedure.

RESULT(S):

The good-quality embryo rate was comparable between the two groups (58.5% with PICSI vs. 56% with Sperm Slow). Overall there were no statistically significant differences in secondary outcome measures except ICSI procedure duration, which was 3 minutes longer in the PICSI group.

CONCLUSION(S):

Both PICSI and Sperm Slow allow comparable clinical efficiency in selecting HA-bound spermatozoa.

CLINICAL TRIAL REGISTRATION NUMBER:

ISRCTN72668039.

[Indexed for MEDLINE]

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