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Fertil Steril. 2012 Sep;98(3):687-91. doi: 10.1016/j.fertnstert.2012.05.045. Epub 2012 Jun 29.

Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk.

Author information

1
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. merritt@jimmy.harvard.edu

Abstract

OBJECTIVE:

To investigate whether galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk, and to determine if this association was modified by lactose intake.

DESIGN:

Two prospective cohort studies and a case-control study.

SETTING:

Academic institution.

PATIENT(S):

A total of 992 cases and 1,050 population-based control samples from a New England case-control study and 240 cases and 900 control samples from the Nurses' Health Studies.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT with the use of the Taqman 5' nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2).

RESULT(S):

Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled risk ratio 1.1 [95% confidence interval (CI) 0.8-1.5] for D1 and 1.0 [95% CI 0.7-1.4] for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake.

CONCLUSION(S):

D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.

PMID:
22749219
PMCID:
PMC3432739
DOI:
10.1016/j.fertnstert.2012.05.045
[Indexed for MEDLINE]
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