Format

Send to

Choose Destination
Biosens Bioelectron. 2012 Oct-Dec;38(1):170-6. doi: 10.1016/j.bios.2012.05.016. Epub 2012 Jun 7.

Slow light engineering for high Q high sensitivity photonic crystal microcavity biosensors in silicon.

Author information

1
Omega Optics Inc., 10306 Sausalito Drive, Austin, TX 78759, USA. swapnajit.chakravarty@omegaoptics.com

Abstract

Current trends in photonic crystal microcavity biosensors in silicon-on-insulator (SOI), that focus on small and smaller sensors have faced a bottleneck trying to balance two contradictory requirements of resonance quality factor and sensitivity. By simultaneous control of the radiation loss and optical mode volumes, we show that both requirements can be satisfied simultaneously. Microcavity sensors are designed in which resonances show highest Q ≈ 9300 in the bio-ambient phosphate buffered saline (PBS) as well as highest sensitivity among photonic crystal biosensors. We experimentally demonstrated mass sensitivity 8.8 atto-grams with sensitivity per unit area of 0.8 pg/mm(2). Highest sensitivity, irrespective of the dissociation constant K(d), is demonstrated among all existing label-free optical biosensors in silicon at the concentration of 0.1 μg/ml.

PMID:
22748964
PMCID:
PMC3432291
DOI:
10.1016/j.bios.2012.05.016
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center