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Lipids Health Dis. 2012 Jul 2;11:85. doi: 10.1186/1476-511X-11-85.

Oxidized low density lipoprotein, stem cells, and atherosclerosis.

Author information

1
Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflammation accompanied with vascular injury. Researchers have proposed that stem cells participate in the formation of atherosclerotic plaque. Also, because ox-LDL is capable of inducing toxic effects on stem cells, it is reasonable to postulate that ox-LDL promotes the progress of atherosclerosis via acting on stem cells. In the present article, we review the relationship between ox-LDL, stem cells, and atherosclerosis and a portion of the associated mechanisms.

PMID:
22747902
PMCID:
PMC3475066
DOI:
10.1186/1476-511X-11-85
[Indexed for MEDLINE]
Free PMC Article

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