Format

Send to

Choose Destination
See comment in PubMed Commons below
Arthritis. 2012;2012:741582. doi: 10.1155/2012/741582. Epub 2012 Jun 18.

Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches.

Author information

1
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA.

Abstract

It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis (OA) is multifactorial and involves the interactions between cartilage and its surrounding tissues. These interactions regulate proinflammatory cytokine-mediated cartilage destruction, contributing to OA progression as well as cartilage repair. This review explores the pathogenesis of OA in the context of the multiple tissue types in the joint and discusses the implications of such complex tissue interaction in the development of anti-inflammatory therapeutics for the treatment of OA.

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center