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Mol Endocrinol. 2012 Aug;26(8):1252-67. doi: 10.1210/me.2012-1107. Epub 2012 Jun 28.

Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

Author information

1
Dame Roma Mitchell Cancer Research Laboratory, School of Medicine, Hanson Institute and University of Adelaide, Adelaide SA 5000, Australia.

Abstract

Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.

PMID:
22745190
PMCID:
PMC3404296
DOI:
10.1210/me.2012-1107
[Indexed for MEDLINE]
Free PMC Article

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