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Nat Cell Biol. 2012 Jun 29;14(7):656-7. doi: 10.1038/ncb2534.

Ubiquitin removal in the TGF-β pathway.

Author information

1
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. massaguj@mskcc.org

Abstract

The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.

PMID:
22743709
DOI:
10.1038/ncb2534
[Indexed for MEDLINE]

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