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Nat Cell Biol. 2012 Jun 29;14(7):654-5. doi: 10.1038/ncb2530.

Get on the exosome bus with ALIX.

Author information

1
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. James.hurley@nih.gov

Abstract

Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

PMID:
22743708
DOI:
10.1038/ncb2530
[Indexed for MEDLINE]

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