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Items: 20


Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

Tian H, Zhang B, Di J, Jiang G, Chen F, Li H, Li L, Pei D, Zheng J.

Cancer Lett. 2012 Dec 1;325(1):26-34. doi: 10.1016/j.canlet.2012.06.007. Epub 2012 Jun 26. Review.


Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.

Wei G, Margolin AA, Haery L, Brown E, Cucolo L, Julian B, Shehata S, Kung AL, Beroukhim R, Golub TR.

Cancer Cell. 2012 Apr 17;21(4):547-62. doi: 10.1016/j.ccr.2012.02.028.


Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis.

Zhou F, Yang Y, Xing D.

FEBS J. 2011 Feb;278(3):403-13. doi: 10.1111/j.1742-4658.2010.07965.x. Epub 2010 Dec 23. Review.


Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA.

Nat Cell Biol. 2011 Sep 18;13(10):1224-33. doi: 10.1038/ncb2330. Erratum in: Nat Cell Biol. 2011 Nov;13(11):1383.


Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis.

Niture SK, Jaiswal AK.

J Biol Chem. 2011 Dec 30;286(52):44542-56. doi: 10.1074/jbc.M111.275073. Epub 2011 Nov 9. Retraction in: J Biol Chem. 2014 Aug 8;289(32):22019.


Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.

Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, Daley GQ, Asara JM, Gygi SP, Wagner G, Liu CF, Yuan J.

Cell. 2011 Aug 19;146(4):607-20. doi: 10.1016/j.cell.2011.06.050.


N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.

Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA.

Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054.


Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells.

Aranovich A, Liu Q, Collins T, Geng F, Dixit S, Leber B, Andrews DW.

Mol Cell. 2012 Mar 30;45(6):754-63. doi: 10.1016/j.molcel.2012.01.030.


Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.


p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.

J Biol Chem. 2012 May 18;287(21):17343-52. doi: 10.1074/jbc.M111.314898. Epub 2012 Feb 21.


The Bcl-2 proteins Noxa and Bcl-xL co-ordinately regulate oxidative stress-induced apoptosis.

Eno CO, Zhao G, Olberding KE, Li C.

Biochem J. 2012 May 15;444(1):69-78. doi: 10.1042/BJ20112023.


Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.

Cruickshanks N, Hamed HA, Bareford MD, Poklepovic A, Fisher PB, Grant S, Dent P.

Mol Pharmacol. 2012 May;81(5):748-58. doi: 10.1124/mol.112.077586. Epub 2012 Feb 22.


Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cells.

Zhang C, Helmsing S, Zagrebelsky M, Schirrmann T, Marschall AL, Schüngel M, Korte M, Hust M, Dübel S.

PLoS One. 2012;7(1):e30684. doi: 10.1371/journal.pone.0030684. Epub 2012 Jan 24.


Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.

Busca A, Saxena M, Kumar A.

J Biol Chem. 2012 Apr 27;287(18):15118-33. doi: 10.1074/jbc.M111.312660. Epub 2012 Mar 8.


Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.

Kwon OH, Kang TW, Kim JH, Kim M, Noh SM, Song KS, Yoo HS, Kim WH, Xie Z, Pocalyko D, Kim SY, Kim YS.

Biochem Biophys Res Commun. 2012 Jun 22;423(1):38-44. doi: 10.1016/j.bbrc.2012.05.063. Epub 2012 May 22.


The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.

Chou FS, Griesinger A, Wunderlich M, Lin S, Link KA, Shrestha M, Goyama S, Mizukawa B, Shen S, Marcucci G, Mulloy JC.

Blood. 2012 Jul 26;120(4):709-19. doi: 10.1182/blood-2012-01-403212. Epub 2012 Feb 14.


3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer.

Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S.

J Nucl Med. 2012 Mar;53(3):443-50. doi: 10.2967/jnumed.111.096503. Epub 2012 Feb 13.


Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.

Arbel N, Ben-Hail D, Shoshan-Barmatz V.

J Biol Chem. 2012 Jun 29;287(27):23152-61. doi: 10.1074/jbc.M112.345918. Epub 2012 May 15.

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