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Psychiatry Res. 2012 May 31;202(2):172-4. doi: 10.1016/j.pscychresns.2011.10.006. Epub 2012 Jun 27.

Dementia in multiple sclerosis: report of a case with cortical gray matter involvement and frontotemporal-like clinical features.

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Department of Psychiatry, Hospital de São João, Porto, Portugal.


Multiple sclerosis (MS) is primarily a white matter disease, but may also involve the gray matter, a feature not often demonstrated in vivo. This report presents the case of a patient with MS and clinical features mimicking frontotemporal dementia due to clear-cut cortical gray matter involvement in the left frontal lobe.

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