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J Bacteriol. 2012 Jul;194(14):3756-7. doi: 10.1128/JB.00692-12.

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).

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1
INBIOTEC (Instituto de Biotecnología de León), Parque Científico de León, León, Spain.

Abstract

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

PMID:
22740677
PMCID:
PMC3393489
DOI:
10.1128/JB.00692-12
[Indexed for MEDLINE]
Free PMC Article
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