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J Virol. 2012 Sep;86(17):9527-30. doi: 10.1128/JVI.01230-12. Epub 2012 Jun 27.

A common strategy for host RNA degradation by divergent viruses.

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1
Department of Plant and Microbial Biology, School of Public Health, University of California, Berkeley, California, USA.

Abstract

Infection with gammaherpesviruses, alphaherpesviruses, and betacoronaviruses can result in widespread mRNA degradation, in each case initiated predominantly by a single viral factor. Although not homologous, these factors exhibit significant mechanistic similarities. In cells, each targets translatable RNAs for cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and the position of the primary cleavage differ. Thus, multiple host shutoff factors have converged upon a common mRNA degradation pathway.

PMID:
22740404
PMCID:
PMC3416159
DOI:
10.1128/JVI.01230-12
[Indexed for MEDLINE]
Free PMC Article
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