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Glia. 2013 Jan;61(1):55-61. doi: 10.1002/glia.22379. Epub 2012 Jun 27.

Microglia and intractable chronic pain.

Author information

1
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Abstract

Many pathological processes within the central nervous system are mediated by complex interactions between neurons and resident glial cells. In the case of painful peripheral neuropathy, spinal microglia react and undergo a series of changes that directly influence the establishment of neuropathic pain states. Purinergic signaling has been shown to be at the center of this reactivity, and here we review recent mechanistic advances describing the importance of microglial P2 receptors and their interactions with neuronal populations in the development of neuropathic pain.

PMID:
22740331
DOI:
10.1002/glia.22379
[Indexed for MEDLINE]

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