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J Surg Oncol. 2012 Dec;106(8):942-6. doi: 10.1002/jso.23202. Epub 2012 Jun 27.

Relationship between histopathology of pleomorphic adenoma in the parotid gland and recurrence after superficial parotidectomy.

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1
Department of Otolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.

Abstract

BACKGROUND:

This study evaluated the relationships between capsular characteristics and recurrence of parotid pleomorphic adenomas.

METHODS:

The pathological slides and clinical data of 110 patients that underwent superficial parotidectomy for pleomorphic adenoma in the parotid gland were reviewed retrospectively. The recurrent and non-recurrent groups comprised 10 and 100 patients, respectively. The two groups were compared with regard to their clinicopathological features, including the capsular characteristics.

RESULTS:

Satellite nodules were observed in six of the 10 recurrent group patients (60.0%) but in only 10 of the 100 non-recurrent group patients (10.0%) (P = 0.001). Five of the recurrent group subjects (50%), but only 11 of the 100 non-recurrent group subjects (11.0%), had positive resection margins (P = 0.006). Perioperative rupture of the tumor was observed in three recurrent group subjects (30%), but in only four of the non-recurrent group subjects (4.0%) (P = 0.016). Multivariate analyses showed that the risk of recurrence was more than fivefold higher when satellite nodules were present (P = 0.010) and more than 14-fold higher when the tumor had ruptured (P = 0.001).

CONCLUSIONS:

Satellite nodules and tumor rupture increase the risk of recurrence in patients with pleomorphic adenomas treated by superficial parotidectomy.

PMID:
22740329
DOI:
10.1002/jso.23202
[Indexed for MEDLINE]
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