Format

Send to

Choose Destination
Nat Rev Cancer. 2012 Aug;12(8):572-8. doi: 10.1038/nrc3299.

From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets.

Author information

1
Cancer Genome Center, Cold Spring Harbor Laboratory, Woodbury, New York 11797, USA.

Abstract

The analysis of human cancer by genome sequencing and various types of arrays has proved that many tumours harbour hundreds of genes that are mutated or substantially altered by copy number changes. But how many of these changes are meaningful? And how can we exploit these massive data sets to yield new targets for cancer treatment? In this Opinion article, we describe emerging approaches that aim to determine which altered genes are actually contributing to cancer, as well as their potential as therapeutic targets.

PMID:
22739505
DOI:
10.1038/nrc3299
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center