Format

Send to

Choose Destination
Oncoimmunology. 2012 May 1;1(3):393-395.

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39.

Author information

1
INSERM; U848; Villejuif, France ; Institut Gustave Roussy; Villejuif, France ; Université Paris Sud; Faculté de Médecine Paris XI; Le Kremlin Bicêtre, France.

Abstract

The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center