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Oncoimmunology. 2012 May 1;1(3):380-382.

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis.

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Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; INSERM; U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; Cnrs; UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Department of Medical Oncology; Centre Léon Bérard; Lyon, France.


Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.

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