Format

Send to

Choose Destination
See comment in PubMed Commons below
Iran Red Crescent Med J. 2011 Dec;13(12):884-90. Epub 2011 Dec 1.

The effect of calendula officinalis in therapy of acetic Acid induced ulcerative colitis in dog as an animal model.

Author information

1
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

BACKGROUND:

In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer. So, a safe and efficient therapy is required for the treatment and prophylaxis for the disease.This study aims to investigate the efficacy of Calendula officinalis extract in treatment of experimentally induced ulcerative colitis in dog animal model.

METHODS:

During fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled. Ulcerative colitis was induced with 6% acetic acid as enema and method of treatment was retrograde (via enema) too by C. officinalis.

RESULTS:

Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of acetic acid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were noticed histologically. C. officinalis could successfully resolve the damages of UC.

CONCLUSION:

Treatment with C. officinalis can broaden the current therapy options for UC.

KEYWORDS:

Acetic acid; Calendula officinalis; Dog; Therapy; Ulcerative colitis

PMID:
22737434
PMCID:
PMC3371898
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center