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Iran Red Crescent Med J. 2011 Nov;13(11):832-6. Epub 2011 Nov 1.

Antibacterial susceptibility patterns and cross-resistance of acinetobacter, isolated from hospitalized patients, southern iran.

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1
Department of Biology, Alzahra University, Tehran, Iran.

Abstract

BACKGROUND:

Acinetobacter is a multi-drug resistant and nosocomial pathogen. The aim of this study was to determine antibacterial susceptibility patterns and cross-resistance of Acinetobacter species.

METHODS:

This study was conducted in Nemazee Hospital, Shiraz, Iran from October 2007 to September 2008. Species identification was carried out by API E20. Minimum inhibitory concentration and cross-resistance of the isolated strains to 12 antibiotics were determined by E-test method.

RESULTS:

Eighty eight isolates of Acinetobacter were collected from patients' samples. Acinetobacter baumannii was isolated most frequently (79; 89.8%). Colistin, imipenem and meropenem were found to be the three most effective antibiotics with 97.7%, 77.3% and 72.7% activity against the isolates, respectively. Multi-drug resistance was revealed among 2 to 11 antibiotics and high cross-resistance was also noticed.

CONCLUSION:

To alleviate the situation, strict control measures and appropriate effective antibiotic therapy should be adopted to reduce hospital costs and related mortality.

KEYWORDS:

Acinetobacter; Antibiotic resistance; Cross resistance; Iran

PMID:
22737424
PMCID:
PMC3371892
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