Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Immunol. 2012 Jun 25;3:159. doi: 10.3389/fimmu.2012.00159. eCollection 2012.

TCR Signaling Emerges from the Sum of Many Parts.

Author information

1
Department of Immunobiology, The University of Arizona College of Medicine Tucson, AZ, USA.

Abstract

"How does T cell receptor signaling begin?" Answering this question requires an understanding of how the parts of the molecular machinery that mediates this process fit and work together. Ultimately this molecular architecture must (i) trigger the relay of information from the TCR-pMHC interface to the signaling substrates of the CD3 molecules and (ii) bring the kinases that modify these substrates in close proximity to interact, initiate, and sustain signaling. In this contribution we will discuss advances of the last decade that have increased our understanding of the complex machinery and interactions that underlie this type of signaling.

KEYWORDS:

CD3; TCR; co-receptor; complex; multi-molecular machinery; triggering

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center