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Front Physiol. 2012 Jun 21;3:188. doi: 10.3389/fphys.2012.00188. eCollection 2012.

Impact of stem cells in craniofacial regenerative medicine.

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Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California Los Angeles, CA, USA.

Erratum in

  • Front Physiol. 2013;4:219. Zhao, Hu [removed]; Bajpai, Ruchi [removed]; Abdelhamid, Alaa I [removed].


Interest regarding stem cell based therapies for the treatment of congenital or acquired craniofacial deformities is rapidly growing. Craniofacial problems such as periodontal disease, cleft lip and palate, ear microtia, craniofacial microsomia, and head and neck cancers are not only common but also some of the most burdensome surgical problems worldwide. Treatments often require a multi-staged multidisciplinary team approach. Current surgical therapies attempt to reduce the morbidity and social/emotional impact, yet outcomes can still be unpredictable and unsatisfactory. The concept of harvesting stem cells followed by expansion, differentiation, seeding onto a scaffold and re-transplanting them is likely to become a clinical reality. In this review, we will summarize the translational applications of stem cell therapy in tissue regeneration for craniofacial defects.


craniofacial; regeneration; stem cell

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