Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Pharmacol. 2012 Jun 22;3:115. doi: 10.3389/fphar.2012.00115. eCollection 2012.

Evaluating the beneficial and detrimental effects of bile pigments in early and later life.

Author information

1
Division of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine Philadelphia, PA, USA.

Abstract

The heme degradation pathway has been conserved throughout phylogeny and allows for the removal of a pro-oxidant and the generation of unique molecules including bile pigments with important cellular functions. The impact of bile pigments on health and disease are reviewed, as is the special circumstance of neonatal hyperbilirubinemia. In addition, the importance of promoter polymorphisms in the UDP-glucuronosyl transferase gene (UGTA1), which is key to the elimination of excess bilirubin and to the prevention of its toxicity, are discussed. Overall, the duality of bile pigments as either cytoprotective or toxic molecules is highlighted.

KEYWORDS:

UDP-glucuronyltransferase; antioxidant; kernicterus; neonatal jaundice; polymorphisms

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center