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Wien Med Wochenschr. 2012 Jul;162(13-14):292-6. Epub 2012 Jun 25.

Arrhythmia-associated cardiac Ca²(+) cycling proteins and gene mutations.

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1
Division of Experimental and Clinical Electrophysiology,Department of Cardiology and Angiology,University Hospital Münster,Albert-Schweitzer-Campus 1 (Gebäude A1),48149 Muenster, Germany. simon.kochhaeuser@ukmuenster.de

Erratum in

  • Wien Med Wochenschr. 2012 Dec;162(23-24):544.

Abstract

Calcium is an important mediator in cardiac excitation and disorders in cardiac Ca(2+) homeostasis have great influence on the cardiac action potential. Therefore dysfunction in regulatory proteins that are involved in Ca(2+) handling can lead to the occurrence of severe arrhythmia. Although mutations in Ca(2+) regulating proteins are quite rare, they can offer general insights into arrhythmogenesis. Here, we briefly review some important aspects of arrhythmia-associated mutations in Ca(2+) regulating proteins with special emphasis to its associated pathophysiology.

PMID:
22733365
DOI:
10.1007/s10354-012-0114-z
[Indexed for MEDLINE]
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